The aim of this work was to study the influence of hot charging contents on the compression strength of corrugated box. The influence of 60 ℃ contents on the compression strength of cartons was analyzed by means of combining theory and experiments, and improvement measures were put forward. Experiments mainly included: contrast experiment in normal temperature environment and constant temperature and humidity room, and contrast experiment of the type 0201 six composite layer of ordinary and waterproof cartons. In 66.7% of the ordinary carton experiment, the compressive strength of experimental boxes fell by 5.5% on average as compared with the control cartons. The compressive strength of Waterproof experimental cartons was superior to that of common cartons by 20% on average. In conclusion, cartons coated with waterproof paint could effectively counteract the effects of hot charging content on the compression strength of cartons.