The aim of this work was to study the rapid design method of coater under the mode of mass customization. Key technologies based on gene engineering theory were proposed and applied in the rapid design process of coater. Methods to realize extraction, amplification, recombination and expression of coater product gene were studied. According to the theory of decomposition reconstruction, all the genetic information of the coater was extracted, starting from module partition of the entity structure and function structure. Saving database table as well as searching and constructing gene library was used to manage the product genes. Gene was amplified by article characteristics table. The configuration design method was used to recombine the target gene and vector gene, and the theory of functional surface was used to express the recombinant gene carrying the genetic information on the model structure. Based on the SolidWorks2012 platform, gene technology-based coater rapid design platform was developed, and structural design, process design and integration of product data management were integrated. A test revealed that the design efficiency of coater was improved by 31%. By applying the gene technology-based rapid design to the company, the labor intensity of designer could be reduced and the development cycle could be shortened. The contradiction between mass customization and individual design was relieved and the actual benefit as well as the market competitiveness of enterprise was enhanced.