The aim of this work was to study the compressive strength of hollow plastic packaging container under conditions of different wall thickness and diameter. SolidWorks software was used to design the 3D model of the packaging container with different wall thickness, different diameter, and different structure, and then finite element analysis was carried out. Through many experiments and data processing, the relationship formula of the plastic container′ s compressive strength and the wall thickness and diameter of the packaging bottle was obtained. After testing it was found that under a carbonated beverage filling pressure of 0.5 MPa, the packaging container was not broken only when its wall thickness was at least greater than 1.5 mm. This test result also provides some help for future design of hollow plastic packaging containers.