A method of tracking and correcting ink presetting curve applicable to the domestic small and medium-sized enterprises was proposed. The characteristics of the ink key opening curve was analyzed and the relationship model of ink key opening curve was established. And then the test file was printed before correcting the curve and the measured density was compared with the standard value, the fine-tuning correction coefficient was set and the corresponding adjustments was carried out to the machine. Finally the data were fitted by Matlab, obtaining the four-color ink key opening curve matched with the experimental conditions. Meanwhile, the fountain roller rotation angle of the four-color CMYK printing machine was marked respectively. The curve was preserved in the printing ink control system for later use. Fine-tuning range and the law of ink presetting curve were found, and the mathematical model for further periodic fine-tuning correction was established. The feasibility of the method was verified by practical production. The corrected curve was able to fulfill the fast and accurate requirements of ink presetting, demonstrating that the practical significance of the correcting method proposed in this paper.