This paper studied the compatibility of poly (ethylene-co-cyclohexane1,4-dimethanol) terephthalate (PCTG) with polyethylene terephthalate (PET) and the processing property of PET/PCTG hot-fill bottles by injection-stretch-blow molding. Crystallinity and compatibility of PET and PCTG were analyzed using differential scanning calorimetry (DSC) curve, thermogravimetry (TG) curve and intrinsic viscosity. PET had good crystallization and PCTG was no-crystallization. PET/PCTG blends were well when PET/PCTG ＜ 32.7% . The cold crystallization temperature of PET was lower in PET/PCTG blends than pure PET. The larger the rate of rising temperature was, the larger the decrease amplitude of crystallization temperature of PET was. PET was well compatible with PCTG and the heat durability of PET/PCTG bottles could be improved by blending with PCTG, but the temperature range of stretch blow molding of PET/PCTG-blended bottles would be narrower compared to PET bottles.