This study aimed to meet the demands of product promotion and education and training about the offset printing machine. The BeiRen J2205 offset printing machine was taken as the research subject. According to composition of the machine and the actual operating process of printing, modeling and assembling of the 3D parts of the offset printing machine was conducted by SolidWorks software. Then the animation of the part assembly process and internal operation process was built by the software 3ds Max. Finally the 3D model was imported into VRP to create a virtual simulation platform. The virtual simulation platform of offset press was finally established which can show the overall appearance of the printing machine, internal parts, assembly process and the animation of internal mechanical operation. The virtual reality technology with the combination of printing machinery can simulate the structure of printing machinery, work flow and related characteristics. It can be used in design of printing machinery and product exhibition.