Through research on design of the centralized ink supply system of rotary offset machine, this study provided a theoretical basis for the design of concentrated ink supply pipeline system in factories and reduce of the adverse phenomenon due to extensive production. Based on the theory of hydrodynamic and the analysis of centralized ink supply system， the relationship between the diameter, the length of the pipeline and the ink viscosity was established. The length of the corresponding pipe was calculated respectively according to the different color ink viscosities, different diameters and pump pressure values. The feasibility of this method was confirmed during reasonable choice of pipe length according to the actual situation in practice. In actual construction, four pipes should be arranged side by side in equal length, the actual pipe length should be less than the designed length and the minimum values of the four values should be chosen in order to guarantee the normal transport of ink in the pipe. According to actual situation and verification in enterprise application, one set of values were adopted as follows, i.e., the pipe diameter was 48 mm with the shortest designed length of pipeline for transporting black ink which was set as 800 m during the actual construction. In conclusion, the circular pipeline hydrodynamics model can be applied to the design of the centralized ink supply system. This research provided a theoretical basis for the design of concentrated ink supply pipeline system in factory and achieved certain social and economic benefits in the process of production, and it can be further popularized.