The aim of this work was to study the comprehensive evaluation system for the design quality of modern packaging machinery. According to the function requirement, the structure features and the corresponding quality characteristics of packaging machinery, referring to the evaluation system of mechanical products, a comprehensive evaluation system for the design quality of packaging machinery was built. Analytic Hierarchy Process (AHP) was then used to determine the subjective weight of the evaluation indexes, while the entropy method was used to determine the objective weight of the evaluation indexes. Furthermore, the subjective weights and objective weights were integrated using the combination method to determine the final weight of the design quality. A case was given for analysis and verification. The case study showed that the evaluation system and evaluation method were feasible. As proven by case analysis, using this evaluation system for the design quality of packaging machinery, the design quality of packaging machinery could be improved and the cost could be reduced.