This work mainly discussed the usage of CPAM-HPCS-PAE complex as a strengthening agent of corrugating medium and the performance enhancement was compared with CPAM andCPAM/HPCS/PAE mixture. The strengthening agent was prepared with hydroxypropyl chitosan (HPCS), CPAM and PAE resin through the cross-linking reaction. All results showed that the optimal addition of CPAM-HPCS-PAE complex was 0.5% , and the dry and wet strength properties of the corrugating medium after the addition of this agent were improved compared with those of CPAM and CPAM/HPCS/PAE mixture. SEM and light scattering results indicated that the intertexture between the paper fibers and the fiber bonding area was efficiently improved after the addition of CPAM-HPCS-PAE complex, thus increasing the strength of paper sheets. In conclusion, both the dry and wet strength properties of the corrugating medium were significantly improved after the addition of CPAM-HPCS-PAE complex.