The aim of this study was to investigate an informationalized packaging anti-counterfeiting technology based on color QR code. First of all, the original information and watermark were transformed into QR code carrier image containing color shading and QR code watermark image according to the encoding principle, and then space conversion of the color QR code was conducted to extract its luminance component. Chaotic scrambling of the watermark QR image was then conducted, and the scrambled watermark image was embedded into the intermediate frequency coefficient after two-level discrete wavelet transform of carrier image luminance component, forming the watermarked color QR code image. Finally, customer terminal could extract the QR watermark from the color carrier QR code image using extraction algorithm. Experiments showed that this algorithm possessed relatively high watermark information embedding strength tolerance, and it could resist geometric attacks like rotation and cropping. Meanwhile it had relatively high robustness against Gaussian noise, salt and pepper noise, low-pass filtering and average filtering attacks. In conclusion, the application of anti-counterfeiting technology combining two-dimensional code and watermark in packaging safety field could facilitate the identification of fake and shoddy goods and the protection of product safety.