The aim of this paper was to study the influence of temperature and humidity on the edgewise crush resistance and bursting strength test programs of the US high-strength double-sided AB corrugated cardboard. Based on the national testing standard in combination with the physical flow environments of product’ s temperature-humidity and the environments of testing equipment for test scheme in this paper， the test temperature was selected in range of -20~40 ℃, and the relative test humidity in range of 40%~90%. Within the range of temperature, every 10 ℃ of temperature and 10% of humidity were set as a group of experiment. The HT-8045A programmable constant temperature and humidity can remain humidity 50% unchanged at the temperature which was below 15 ℃. According to the actual situation and national standard, there were 22 points selected for the test of temperature and humidity study. Experiment results were obtained at 22 test points. Meanwhile, the cardboard edgewise crush resistance and bursting strength variation with respect to temperature and humidity according to the mechanical model were analyzed by using the data and curves obtained from the origin software. The change rule of cardboard edge compression strength and bursting strength with the different temperature and humidity was concluded. It was verified that the temperature changes had little effect on the edge compression strength, with a maximum relative error no more than 7.34% in the range of 40% to 70%. Temperature changes had little effect on bursting strength, and the maximum relative error was less than 11.83% in the range of 40% to 90% . Hence, attentions should be focused on the impact of transportation and storage environment humidity on paperboard strength during the corrugated packaging design. The experimental method can be referred for the cardboard box design of similar type materials.