The aim of this work was to optimize the structure and layout of folding carton to improve the utilization rate of paperboard in production. The layout design schemes of folding carton were optimized based on the layout influencing factors. In actual production, the layout scheme should be flexibly chosen according to the carton structure. The paperboard size and grain were also key factors for layout scheme. According to the demand of layout, part, overall, or comprehensive structure optimization strategies could be used to modify the folding carton structure, resulting in reasonable structure and compact layout. In conclusion, layout design of folding carton needs comprehensive consideration of various factors, and then the optimal layout scheme can be proposed in the premise of implementation.