The aim of the study was to prepare a safe and environment friendly adhesive composed of modified corn starch. Using polyvinyl alcohol and corn starch as raw materials, potassium permanganate as oxidant, boric acid as cross-linking agent, and water as solvent, the synthesis conditions of modified corn starch adhesive were studied. Using single factor variable method, the effects of factors such as dosage of materials, oxidant dosage, dosage of dextrinizing agent, pH and dosage of cross-linking agent on the product properties were investigated. The optimal technological parameters were found be as follows: 360 g Water, 30 g corn starch, 0.0045 g potassium permanganate, 100 g polyvinyl alcohol, 0.054 g boric acid, 2.4 g sodium hydroxide, and some calcium chloride, urea, alcohol, and defoamer. The product synthesized under this condition was a semi-transparent sticky liquid with a viscosity of 70 Pa·s. In conclusion, the overall performance of the product was high. The product was appropriate for applying to the production line of beer industry.