This research aimed at improving the stability of the packaging proper piece and the force transmission performance of packaging machine institutions of mushroom medium. The model of the machine was parameterized, simulated, and optimized in ADAMS. The maximum horizontal reaction force FOx max, FJx max and the maximum acceleration apis max of the packaging proper piece was included in the multi-objective design evaluation function in the optimal designed mathematical model, and the motion angles between components were taken into account as the constraint conditions of optimal design. In simulation, the highly sensitive θ1 and θ3 were chosen for optimization and their range were decided to eliminate low-quality parameters. By comparative and comprehensive dynamic optimization, it was advantageous to select a combination of superior parameters (including the combination of the design parameters θ1 and θ3) specific to objects and targets. The maximum reaction force on each support shaft was reduced by 30% ~40% and the maximum acceleration of the packaging proper piece was reduced by 34.4%. The simulation experiment showed the influence of the single parameter may be concealed by the coupling effect of the multi-parameter optimization. However, the CAE software allowed independent modification of single parameter, thus ensuring the standardized structure parameters to be directly applied to engineering.