This paper studied the effect of different initial temperatures on the temperature field in the spray sterilization process. This paper designed the heat conduction model of PET bottled drinks in the spray sterilization process with finite element analysis software ANSYS, which was loaded with temperature, taking water as the spray medium. The temperature distribution of PET bottled drinks was greatly influenced by the initial temperature in the spray heat sterilization process, but the high-temperature region was always located at the center of the bottle shoulder. The higher the initial temperature of PET bottled drinks was, the larger the proportion of the high temperature region in the final temperature field was and the greater the value of the maximum temperature was, besides the shorter the time it needed to reach to the same temperature. An appropriate increase of the initial temperature could guarantee the sterilization effect and shorten the sterilization time.