This experiment developed a novel high-strength and moisture-proof corrugated box for refrigeration to adapt to the logistics environment of low-temperature storage and transportation of cold-chain food. By testing the packaging features of the warp and weft paper, the composition of corrugated box was determined. The finite element models of the warp and weft corrugated box and the ordinary corrugated box were established by use of Ansys software to simulate the actual environmental load imposed on the models and calculate the compression strength. The compression strength test on empty box was also conducted to compare the compression strength of the two kinds of corrugated boxes. The results showed that in the logistics environment of low temperature, the compression strength of the box made by warp and weft paper was 30% higher than ordinary corrugated boxed and the weight of the warp and weft box was 12% lower. In practical production， the warp and weft paper can be used to make high-strength and moisture-proof corrugated box which is suitable for the cold-chain logistics environment. This kind of paper also can be used to make boxes of lower weight and higher strength, which can save paper usage.