This article studied the principle and practical application of digital anti-counterfeiting technology. Digital anti-counterfeiting verification theoretical model and consumer query model, as well as the digital anti-counterfeiting principle and typical digital anti-counterfeiting technology were introduced, based on which, the combined application of 2-D barcode and RFID anti-counterfeiting technology was explored. Both 2-D barcode and RFID anti-counterfeiting technology were in accordance with the product anti-counterfeiting verification theoretical model, and the RFID anti-counterfeiting technique had a higher level of safety than 2-D barcode. With the development of digital anti-counterfeiting technology, digital anti-counterfeiting must be one of the major trends of future anti-counterfeiting technology.