The aim of this study was to develop an explosion-proof gantry palletizing machine so as to improve the automation of palletizing equipment in the explosive dangerous places, reduce the labor intensity, raise the efficiency of labor, and diminish the cost of production. An explosion-proof gantry palletizing machine was designed and manufactured which was one kind of flameproof apparatus. The hardware and software of palletizing control system in which PLC was applied as the control core was designed with reasonable explosion-proof components. The application of touch screen and switch button in the flameproof system was researched. The motion structure of the palletizing machine was analyzed, and a fuzzy-PID algorithm was used. The explosion-proof gantry palletizing machine designed reached explosion grade, ran stably and reliably, had the repeated positioning accuracy that could meet the work requirements, and enhanced the product efficiency greatly. The application of touch screen and switch button successfully solved the difficulty that the parameters could not be easily adjusted in the flameproof system. The palletizing machine which was frequently used in a paint plant had an excellent market prospect and value of promotion.