To investigate the migration of 17 residual organic solvents in food packaging paper under different migration conditions. Contaminated samples were prepared. The migration rate of residual solvents in different kinds of food was determined. At the same time, the influences of migration time, migration temperature, food properties, microwave irradiation and ultrasonic vibration on residual solvents migration were compared, and variation curves of migration rate were depicted. Migration time, migration temperature, food properties, microwave irradiation and ultrasonic oscillation all had influence on the migration rates of the residual benzene and other organic solvents. The equilibrium migration rate would reach a high level in a shorter time at a higher temperature. The equilibrium migration rate of benzene and other organic solvents at 100 ℃ was 2.8 and 2.3 times as high as those of 25 ℃. The effect of food properties was determined by their polarity and compatibility, while microwave irradiation and ultrasonic vibration could speed up the migration. The results showed that the migration rate of residual solvents was subjected to the comprehensive influences of multi-factors. Research on migration regularity in food packaging paper has a great value in its safe application and preserving food safety.