Research the human-machine relationship in medicine packaging machine. Use actual cases， visiting factory and literature researching，according to the particularity of medicine packaging machine，it researched multiple levels of human-machine systems. Designers should be focus on the particularity of operation，cleaning and maintenance in human-machine relationship of medicine packaging machine，also should consider scale，light，sound，and other factors， and design for a harmonious system with＂human- machine- environment＂.