Design a household intelligence medicine case for old people based on the relative theory of human factor and barrier-free design. A model of human-machine interface of the intelligence medicine case was built. The intelligence medicine case was designed by single-chip microcomputer and mechanical structure. The visual, auditory and touch interface of the intelligence medicine case were human-centered designed for old people. Single-chip microcomputer was applied to control display of sound and text indicators of taking medicine. Mechanical equipment was used to achieve the function of medicine box openning automatically. Barrier-free human factors design of household intelligence medicine case for old people considered the physiological and psychological characteritics of the older. This intelligence medicine case can remind old people to take medicine on time and accurately.