To design a type of cosmetics E-Commerce packaging to achieve the goal of changing the situation of existing cosmetics E-Commerce packaging. Aiming at the structure characteristics of existing cosmetics E-Commerce packaging, some issues of the common cosmetics E-Commerce packaging were analyzed, such as excessive packaging, poor packaging protection performance, hardly recyclable packaging, and poor convenience. Four design objectives were made on this basis, the cosmetics E-Commerce packaging was optimized towards the direction of strengthened protection function, size standardization, reusability and easy operation. A type of cosmetics E-Commerce packaging suitable for six different sizes of products was designed, which was environment friendly, economical and efficient. Using this newly designed packaging to gradually replace the traditional E-Commerce packaging could reduce the cost and the pollution of environment, and meanwhile improve the protection. It would be beneficial for the sustainable development of economy, and could provide ideal packaging solution for the future E-Commerce packaging.