Objective To study the way to lower the concentration of alcohol in alcohol dampening. Methods First, FS12-100 dampening solution and pure water were used to make the original solution with 3% of FS12-100 dampening solution and the surface tension was tested. Then different concentrations of alcohol and the surfactant‘6501’were added separately and together to test the different surface tensions. Results Based on the experimental data, addition of 0.1% of ‘6501’and 5% of alcohol in the fountain solution could reduce the concentration of alcohol from 12% to 5%, achieving the lowest surface tension, 23.37 mN/m. Conclusion Preparation of novel low-alcohol fountain solution by mixing the surfactant '6501' and alcohol was feasible.