Objective To study the optimal heat-seal parameters of the cladding layer in the manufacturing process of the aircraft sound insulation cotton. Methods The effects of different heat-seal processing parameters (heat-seal temperature, time and pressure) on the cladding layer heat-seal intensity of sound insulation cotton were analyzed, and mathematical models were established for main heat-seal parameters and heat-seal intensity. Based on this, heat-seal intensity was simulated and heat-seal parameters were optimized by LabVIEW software, in order to verify the mathematical models. Results The model calculated data was essentially identical to the experimental data, and the accuracy of the model was verified. Conclusion The optimization of heat-seal parameters was realized, which provides reference for setting the seal-heat parameters in the sound insulation cotton heat-seal processing of an aircraft manufacturing company.