Objective To study and develop a driving power for piezoelectricity used in ink-jet printer. Methods In this paper, the circuit design method of piezoelectricity ceramic power supply was proposed， which was based on AT89C52 and CPLD. The effects of anti-interference, ripple and phase compensation were taken into account during the designing process. The control circuit board was developed and the control software was programmed. At last, experimental validation was conducted. Results The maximal output voltage was ±100 V( peak to peak) and its output current was in the range of 0-5 A. The width of driving pulse was digital adjustable. Conclusion The unique features of this design included high precision, low ripple, strong driving capability and high stability. This study could provide theoretical and technical support for design of inkjet printing drive power.