Objective To study the scanning algorithm of laser die-cutting. Methods Through writing the control program of laser die-cutting, the vector graphics could be read and the G code could be generated automatically, and then the preview of cutting process could be displayed in animation form. If any problem was found during the preview, the G code could be modified accordingly. Accordingly, a more perfect lower machine control program would be generated automatically. At last, a experimental device was set up to verify this scanning algorithm. Results The scanning algorithm could control the die-cutting trajectory of the laser beam, the maximal processing error was ±0.05 mm, and the results of laser die-cutting were relatively ideal. Conclusion The laser die-cutting control system based on this scanning algorithm could realize fully digital die-cutting for the moving printed matters in production line.