Objective To study the mould design and NC machining of packaging container based on Pro/E and Mastercam. Methods With the use of Pro/E software, using beverage bottle as an example, model and mould design were proceeded, and by converting the graphics data to Mastercam software, a detailed analysis of mould machining process was proposed, which included formulation of processing scheme, and setting up of machining parameters respectively for cavity roughing, semi-finishing, finish machining and flow cut. Results The beverage bottle mold NC automatic programming and simulation machining were carried out through the realization of geometric modeling, cutting tool path, post processing and simulation, and also NC program was obtained. Conclusion Practice showed that with the use of Pro/E and Mastercam combination, giving full play to the advantages of each software function, the quality and efficiency of the packaging container mould design and NC machining could be improved.