Objective To explore the basic principle and experimental method of acoustic emission testing technology from leakage in drums, the drums leakage model and experimental model were established. Methods First, the AE signal generating mechanism and the fluid-structure interaction basic theory from leakage of gas in drums were introduced. Then the model of drums leakage was built, the structural response characteristics under flow-induced vibration was simulated using fluid-solid coupling method with Workbench. According to the principle of acoustic emission detection, the experimental platform of drums leakage was built, the experimental data was collected and analyzed. Correlation between characteristic parameter and internal pressure or leak diameter was discussed, and the waveform of frequency domain was analyzed, so as to obtain characteristic parameters and characteristics of vibration frequency which can be to characterize the leakage of drums. Finally, the leakage acoustic emission signal characteristics was compared with the results of simulation. Results The results showed that the exciting frequency of flow-induced vibration from leakage of gas in drums was 22~40 kHz, and the peak frequency was 25 kHz. Conclusion The structural response result of simulation and experimental detection of drums leakage were basically consistent. The simulation and experimental research methods of drums leakage provide a theoretical basis for researching online test for leakage of gas from drums.