Objective In order to solve the problem of the significant color difference between digital samples and printing samples in Photoshop color management, a new method was put forward to correct ICC Profile. Methods The gray color difference characteristics of digital samples, as the research object, were analyzed based on both GMG and Photoshop color management workflow. Furthermore, the gray balance data in ICC Profiles was optimized using ProfileEditor software based on the theory above. Results Using the adjusted ICC Profile in the Photoshop color management process, the average color difference of neutral gray was decreased from 8.0863 to 4.2284 on imitation coated paper, and decreased from 10.1063 to 5.5908 on imitation specialty paper. Conclusion The color differences between the printing samples and digital samples were decreased by optimization of gray balance parameters in ICC Profile, which improved the accuracy of color reproduction.