To analyze contemporary international design strategy，management scientific research and industrial application status，construct the design strategy and management knowledge framework of a new era adapted to new economic form and target system oriented by innovation. It made a horizontal comparison of the similarities and differences between the four categories of innovation system of in America， England， Italy and China as the representative of the longitudinal analysis， such as "the product level"， " the enterprise level"， "the industry level"and "the social level "innovation system evolution and the future trend，and made in-depth analysis of extracting the innovation system in four key elements： "life style"， "business model"， "design thinking"and"new product development". It constructed the systematic，dynamic and multi-level model design strategy and design management knowledge framework， in order to provide reference of relatively complete knowledge structure from the design angle for the Chinese enterprises which are facing the dilemma of innovation.