Objective To study the effects of the thickness and thermal conductivity of insulation material, the convection coefficient and the temperature on the holding time of a typical latent-heat insulation package. Methods A model was built for the typical latent-heat insulation package system by computer, and was then imported into Ansys. The thickness and thermal conductivity of the insulation material, the convection coefficient and the temperature were changed in the model, and the time required by the mimic to first reach the critical temperature was set as the holding effective time. The effects were studied. Results The holding time was obviously influenced by the thickness, and there was a positive correlation. At lower values, the changes of the convection coefficient, the thermal conductivity and the temperature had obvious impacts on the holding time. Conclusion At a certain amount of coolant, the typical packaging system was significantly influenced by the thickness of the insulated container, and the convection coefficient, thermal conductivity and temperature exerted obvious effects in a small range.