Objective To research the intelligent control system and human-machine interface design approach of bag-making equipment. Methods Based on PLC and touch screen technique, the overall design scheme of control system was made. Also, the system structure, function planning and human-machine interface of bag-making machine were researched and designed. Results Intelligent control of the system for the process of bag-making was verified by the tests of equipment. In conformance with the cognitive habits of the users, the control system could be easily operated. Conclusion Through the modification design of control system and human-machine interface for bag-making equipment, the product quality and efficiency could be effectively improved.