Objective To establish a prediction model of insulating package shelf life to prevent temperature sensitive product from being influenced by temperature during the available period. Methods An available period prediction model for the typical insulating package of rectangular product was established by calculating the thermal resistance of insulating container and the total heat absorption of refrigerant. The validity of the proposed model was confirmed by experimental data based on storage experiment of two typical insulating packages at three temperatures (296, 308, 318 K) . Results The experimental values were larger than the model values. But the deviations were below 10% . Conclusion The result indicated that the proposed model could accurately characterize the shelf life of insulating package, which provides theoretical reference for the design of insulating packages.