Objective To investigate the feasibility of simulating microwave heating of packaged food by COMSOL Multiphysics . Methods A time-dependent electromagnetic and heat transfer coupling model was established to simulate the process of microwave heating of food by FEM software COMSOL Multiphysics,and the simulation results were compared with experimental results. Results The results showed that the simulation results of food temperature distribution were similar to the experimental results, the simulation results of 7 feature points were close to the experimental results,and the root mean square error of final temperature of feature points between experimental results and simulation results was 1. 75 ℃ . Conclusion It was confirmed that the simulation of microwave heating of packaged food by COMSOL Multiphysics is feasible.