Objective To develop a multi-residue method for the analysis of 7 indicator polychlorinated biphenyls ( PCBs) , 7 plasticizers, 7 chlorophenols ( CPs ) , 2 benzophenones, as well as 4- octylphenol ( 4- OP ) , 2- isopropyl thioxanthone ( ITX) , and methyl stearate in food packaging paper material. Methods Ultrasonic extraction and gas chromatography-tandem quadrupole mass spectrometry in multiple reaction monitoring ( MRM) mode was used. Results All of the 26 organic residues had good linear relationship ( r^{2>0. 997) in the range of 0. 02 ~ 2. 0 mg / kg. The recoveries of the 26 organic residues ranged from 88. 9 % to 105. 5 % at spike level of 0. 1 mg / kg with relative standard deviation ( RSD) below 12. 2 % . The detection limits of target compounds in the method were between 0. 000 90 mg / kg and 0. 0035 mg / kg. The quantification limits of target compounds in the method were between 0. 0031 mg / kg and 0. 012 mg / kg. The method was applied to the analysis of real samples, and plasticizers were detected in almost all of the samples ( the amount detected was between 0. 006 ~ 7. 02 mg / kg) , and methyl stearate was detected in part of the samples ( the amount detected was between 0. 069 ~ 0. 43 mg / kg) . Conclusion The method is simple, quick, accurate and sensitive, and applicable for the simultaneous and high through- put determination of multi-organic residues in food packaging paper material and samples with similar matrixes.}