Objective To study the comprehensive evaluation method and evaluation model for the perceptual non-uniformity quality of large areas in digital prints. Methods The non-uniformity quality metric was calculated to measure the integrated non-uniformity of the digital prints based on noise power spectrum and human vision transfer function, the subjective perceptual evaluation scale was obtained through psychophysical experiment, and the quality evaluation model for the visual perception of digital prints爷 non-uniformity was created based on the objective and subjective quality evaluation experiments for 200 digital printed patches. Results The results showed that the quality metric well reflected the perceptual quality of the large printed area, and the evaluation model provided a valid quantitative and comprehensive evaluation results. Conclusion It is feasible and practical to evaluate the non-uniformity of digital prints comprehensively and quantitatively.