The main factors influencing uncertainty of edgewise-crushed resistance of corrugated box were analyzed and measured according to JJF 1059. 1—2012 Evaluation and Expression of Uncertainty in Measurement. The results showed that the source of uncertainty mainly comes from repeated test, accuracy of equipment, and rounding off of value; the uncertainty of edgewise-crushed resistance of the corrugated boxes is U =(8. 94±0. 23)×103 N/ m, k =2.