The socks are taken as an object of packaging. Considering the requirements of bag packaging and the characteristics of socks, gusseted bag suited to not only one pair but also multiple pairs was designed. The parameterization design of gusseted bag was carried out and a optimization method suitable for structure parameter optimization was put forward. A serialization design method of socks gusseted bag was put forward combining properties of socks and gusseted bag. A series of bag type were designed and the corresponding relationship between socks and bags was built by taking one pair of socks for example. It proved that parameterization design and serialization design of gusseted bag are reasonable through specific instances.