A high-efficient cell-search method for CYNSN model was proposed, which included framing initial cell by ordering the training sample set, searching optimal cell using the priority in difference method step by step, and expanding initial cell. Experimental result showed that the proposed cell-search method can make the backward CYNSN model copy accurately in spectral and colorimetric reflectance; compared with existing CYNSN model, the CYNSN model using the proposed cell-search method improves efficiency more than 10 times with the same precision.