The research status of intelligent printing quality detection system PressSIGN of well-known color management company at home and abroad was introduced. The key technologies of comprehesive printing inspection system PressSIGN were introduced from the aspects of intelligent manufacturing, printing density control, supporting for multiple international printing standards, CTP curve compensation, supporting for dry and wet printing, automatic generation of color control bars, etc. . The future development trend of PressSIGN system was prospected.