Model of wine bottle packaging mechanism was established and optimization was carried out based on ADAMS. Motion pair model of linkage with clearance caused by manufacturing and assembling error was established based on clearance vector model. The kinetic relationship between two linked bodies was obtained, and the dynamic relationship based on the model of nonlinear contact force was also presented. The influence of clearance of motion pair on kinetic and dynamic characteristics of the system was analyzed. The result showed that ADAMS simulation is a kind of effective method to study motion pair with clearance, which can provide accurate prediction for design and dynamic description of multi body mechanism; It has universal significance for analysis of other mechanism with clearance.