As a commonly used mechanism in automatic machine, especially in the field of automatic packaging machine, conjugate cams have the advantages of high efficiency, high accuracy and high reliability. Parametric simulation technology was used in conjugate cam mechanism design. The 3D modeling processes of conjugate cam and principle of mechanism motion simulation were introduced. The theoretical and practical profiles of conjugate cam can be created quickly using graphical reverse method and analytical method based on the motion simulation and trace generation functions of Creo Parametric software.