Influencing factors on moisture barrier performance of lipids-CMC edible film were studied, which contained carboxymethyl cellulose as the main film material, and lipids and plasticizers as additives. The sequence of factors on water vapor transmission rate is beeswax> CMC content> stearic acid> PEG400> water/ethanol. The result indicated that with the increase in stearic acid and beeswax content, the film's water vapor transmission rate, mechanical properties, and oil resistance decreases, but its oxygen barrier increases; with the increment of CMC, ethanol and PEG400 content, film's water vapor transmission rate first decreased and then increased. The optimum composition ratio for water vapor barrier performance is water/ethanol (95/5), stearic acid (0.02 g/mL), PEG400 (1.5%), the wax (0.004 g/mL) and CMC (0.03 g/mL).