Indirect and direct inverse sub-structure dynamic analysis were applied to calculate the coupling dynamic stiffness of a specific assembly of product-packaging-vehicle system on the basis of measured frequency response functions (FRFs) at system and component level respectively. A set of experimental model was designed and constructed, and a number of tests, computations and analysis were implemented to verify the effectiveness of engineering applications of the two methods for anti-shock design of a practical product-packaging-vehicle system.