Quick and effective cost estimation of product packaging can be used for quick response of customer inquiry, quotation and other aspects of demand on packaging price of product, and it can also provide support on technical and economic evaluation of product packaging design scheme for reduction of product packaging cost. In view of the characteristics of product packaging, a case retrieval process was presented. The idea of hierarchical case-based reasoning and the method of combination of knowledge instruction strategy and nearest neighborhood strategy were adopted. The method of product packaging cost estimation based on similar cases was proposed. The cost estimation of turbine bypass product packaging was taken as an example to verify the feasibility and validity of the method.