Combined with the technique characteristics of ink-jet digital printing, a quality detection method based on traditional printing quality detection theory and CCD machine vision technology and closed loop color control system was designed. Based on chromaticity deviation theory and method, the grey balance, dot enlargement and uniformity was discussed through the experiment and data analysis. The result showed that the revised color deviation fluctuation quickly reaches to the target state level; the effect after compensation is much better than before. This method is proved to be more effective for high-accuracy automatic on-line detection and control of ink-jet digital printing quality.