A new kind of sealing structure for packaging bottle was designed according to the characteristics of special shape and good extrusion with the focus of metrological control. The new sealing structure has the combination of tamper-evident packaging, child restraint, easy to use and funny. Metrological control scheme based on transparent loop was selected, functional structure was determined, size parameters of main components were designed, and the parts display drawing and overall exploded view was drawn. The design scheme has the characteristics of simple structure, user-friendly, and low cost.