Fair Packaging and Labeling Act, Presidential Action Project and Food Safety Enhancement Act ( H.R. 2749 ) was analyzed and gravity model was used to test the effect of these food packaging safety regulations on international trade. The research showed that though the amendments of U.S. food safety regulations hindered food exports to varying degrees, they also promoted the food exports in parts of countries. According to the inherent characteristics of food packaging safety regulations and the experience to succeed in other countries, it was concluded that improving own food packaging safety regulations and looking for the formation mechanism of positive effect of U.S. food safety regulations is an effective countermeasure.