Traditional wallpaper packaging technology has the weaknesses of waste of human and financial resources. The working principle of wallpaper packaging machine was analyzed. A wallpaper packaging control system was put forward, which use FX2N series PLC from Japan Mitsubishi Company as the main controller. The hardware configuration of wallpaper packaging machine based on PLC, the distribution of I/O point and software design were discussed. The results showed that the control system of wallpaper packaging machine based on PLC and HMI, makes system control easy, operation reliable, cost effective, and has the very good practicability.