Three-dimensional digital prototype of intermittent mechanism of die-cutting machine and its work system were established mainly using software platform of Pro/E and ADAMS. Kinematics and dynamics simulation analysis of intermittent mechanism was carried out systematically. Computer simulation of motion rule of the intermittent mechanism output shaft and the contact force between cam and roller of sector gear during working phase of the intermittent mechanism were realized. The feasibility of replacing traditional intermittent mechanism with the new intermittent mechanism was verified.